Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
Sandargo B, Thongbai B, Praditya D, Steinmann E, Stadler M, Surup F. Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea. Molecules. 2018 Oct 19;23(10). pii: E2697. doi: 10.3390/molecules23102697.
Tropical rainforest, Queensland, Australia. Photo by Dr. Rohan Davis.
Analytical equipment. Photo by Atanas G. Atanasov.
Hep-2 signal activated cells. Image by Dr. Vassilis Doucas.
Flower blossoms at gardens by the bay Singapore-photo by Dr. Hemanth Kumar Boyina.
Saffron plants, Zapponeta (Foggia), South of Italy. Photo by Dr. Grazia D'Onofrio.
Blood cells colored with fluorescence dye. Photo by Dr. Davide Barreca.