Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells
Abstract:
Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3-6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1-2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.
Hegazy MF, Hamed AR, El-Halawany AM, Hussien TA, Abdelfatah S, Ohta S, Paré PW, Abdel-Sattar E, Efferth T. Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells. Fitoterapia. 2018 Oct;130:54-60. doi: 10.1016/j.fitote.2018.08.002.
Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells
Tropical rainforest, Queensland, Australia. Photo by Dr. Rohan Davis.
Analytical equipment. Photo by Atanas G. Atanasov.
Hep-2 signal activated cells. Image by Dr. Vassilis Doucas.
Flower blossoms at gardens by the bay Singapore-photo by Dr. Hemanth Kumar Boyina.
Saffron plants, Zapponeta (Foggia), South of Italy. Photo by Dr. Grazia D'Onofrio.
Blood cells colored with fluorescence dye. Photo by Dr. Davide Barreca.
The Botanical Garden of Department of Pharmacognosy, University of Vienna, Austria. Photo by Atanas G. Atanasov.
Lagoon of the seven cities, a twin lake in the crater of a dormant volcano in the western part of the São Miguel island (Azores, Portugal). Photo by Dr. Ana Sanches Silva.
Central Australian desert scene. Photo by Dr. Rohan Davis.
HEK293T cells. Photo by Atanas G. Atanasov.
Tropical rainforest, Queensland, Australia. Photo by Dr. Rohan Davis.
Australian ocean scene. Photo by Dr. Rohan Davis.
Laboratory equipment. Photo by Atanas G. Atanasov.
Rhododendron arboreum flower. Photo by Devesh Tewari.
The Valley of Flowers, Himalaya, India. Photo by Dr. Rajeshwari Singh.
Bryce Canyon, Utah, USA. Photo by Dr. Anupam Bishayee.
Euphorbia prolifera Buch. (Ham) Ex. Photo by Devesh Tewari.
Foothills of Himalaya, India. Photo by Devesh Tewari.
The Valley of Flowers, Himalaya, India. Photo by Dr. Rajeshwari Singh.
Eco-School Festival, Leiria-Portugal, Spring 2018
Polygonum maritimum (L.) (Polygonaceae)- Ourdania beach (Ain Temouchent- west Algeria)- taken by PhD. EL HACI Imad Abdelhamid
Flower blossoms at gardens by the bay Singapore-photo by Dr. Hemanth Kumar Boyina.
Keywords: cytotoxicity, abietane diterpenoids, Salvia multicaulis, multidrug-resistant cancer cells, CCRF-CEM, CEM-ADR5000, HRESIMS, 1D-, and 2D-NMR, salvimulticaoic acid, salvimulticanol.
