Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
Full text of the study can be accessed at the website of the publisher, can be obtained by one-click-request on ResearchGate (by hitting the “Request full text” button), or can be supplied on demand by email request to [email protected]
Citation information: Atanasov, A.G., et al. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov (2021). https://doi.org/10.1038/s41573-020-00114-z
Natural products in drug discovery: advances and opportunities https://t.co/RRAk9GCTsG
INPST-based collaborative work that we just published in Nature Reviews Drug Discovery (DOI: 10.1038/s41573-020-00114-z).#INPST #Pharma #Pharmaceuticals
TY to all @_INPST collaborators pic.twitter.com/M5J6vPptrC
— Atanas G. Atanasov (@_atanas_) January 31, 2021