COLLABORATION CALL: MOLECULAR MECHANISM LINKED WITH THE INHIBITION OF eEF2 IN CANCER.

We have expertise working with elongation translation by studying eElongation Factor-2 (eEF2) in the aging and oxidative stress conditions https://pubmed.ncbi.nlm.nih.gov/33425211/, and now we have some preliminary results showing a potential new mechanism of eEF2 in cancer. In fact, overexpression of eEF2 has been reported in several cancer types, and depletion of eEF2 with shRNA decrease the growth of cancer cell lines.

Due to, so far, very few specific translation elongation-inhibitors targeting eEF2 are available, for example:

We are currently looking for a collaboration within our project for providing some of these compounds.

Happy to discuss further

Best regards

Sandro

 

Prof. Sandro Argüelles, PhD [email protected]

Department of Physiology, Faculty of Pharmacy & Biology, University of Seville |Seville, Spain |