COLLABORATION CALL: REPURPOSING OF SOME BIOACTIVE NATURAL PRODUCTS TO CONTROL COVID-19 INFECTION: A MOLECULAR DOCKING STUDY

Dear INPST colleagues, we are currently looking for a collaboration within our project, aimed through molecular docking (MD) to study and track the possible interactions of certain natural products including celastrol, pristimererin, tingenone, iguesterin and quercetin-3-b-galactoside with 3CLpro of SARS-CoV2 as well as possible interactions of tanshinone I and hirsutenone with PLpro of SARS-CoV2.

 

Compounds showed potential inhibitory activity, via MD, against PLpro of SARS-CoV2, were Glycyrrhizin, Saikosaponin B2, Saikosaponin_A, Amentoflavone, Solasodine, Tingenone, Kolaviron, Pseudo-Ginsenoside F11, Iguesterin, Celastrol, Solanine.

 

Therefore, we are in particular interest to find a collaboration for providing these later 11 compounds to be tested using the PLpro of SARS-CoV2 assay kit, that we already purchased (for compounds with molecular weight less than 500, about 5-10 mg should be enough. For compounds with higher molecular weight, we need about double that amount).

We are a group of pharmacists, with different specialties working together on this project. We are happy to provide any details if you are interested.

…………………………………………

Dr. Nadia Hamdy

[email protected]

Prof. of Biochemistry, Project PI, Dept. Head,

Department of Biochemistry and Molecular Biology

Ain Shams University
Faculty of Pharmacy
Cairo, Egypt