NTZ Lab Ltd. has developed new promising brain-penetrant compounds, the discovery of which is described in our latest publication in the European Journal of Medicinal Chemistry.
We develop a series of promising BBB permeable derivatives combining both high potency and selectivity with optimal physicochemical and drug-like properties required for CNS active drugs. NTZ-2020 exhibits a neuroprotective effect on cortical neuron survival and induces neurite network outgrowth. These effects are associated with a good BBB penetration in a triple cell neurovascular unit (NVU) model.
Nikolay T. Tzvetkov, Hans-Georg Stammler, Silvia Hristova, Atanas G. Atanasov, Liudmil Antonov. (Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons. European Journal of Medicinal Chemistry, 2018, https://doi.org/10.1016/j.ejmech.2018.11.009
Keywords: NTZ Lab, ADME, MAO-B inhibitors, Neuroprotection, Parkinson’s disease, brain-penetrant compounds, BBB permeable drug leads, monoamine oxidase B inhibitors, neuroprotective effects, cortical neuron survival, neurite network outgrowth, MAO-B.
The International Natural Product Sciences Taskforce (INPST) maintains up-to-date lists with conferences, grants and funding opportunities, jobs and open positions, and journal special issues with relevance for the area of phytochemistry and food chemistry, pharmacology, pharmacognosy research, and natural product science.