Development of new highly potent drug leads for disorders of the central nervous system

NTZ Lab Ltd. has developed new promising brain-penetrant compounds, the discovery of which is described in our latest publication in the European Journal of Medicinal Chemistry.

We develop a series of promising BBB permeable derivatives combining both high potency and selectivity with optimal physicochemical and drug-like properties required for CNS active drugs. NTZ-2020 exhibits a neuroprotective effect on cortical neuron survival and induces neurite network outgrowth. These effects are associated with a good BBB penetration in a triple cell neurovascular unit (NVU) model.

Publication information

Nikolay T. Tzvetkov, Hans-Georg Stammler, Silvia Hristova, Atanas G. Atanasov, Liudmil Antonov. (Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons. European Journal of Medicinal Chemistry, 2018, https://doi.org/10.1016/j.ejmech.2018.11.009

Keywords: NTZ Lab, ADME, MAO-B inhibitors, Neuroprotection, Parkinson’s disease, brain-penetrant compounds, BBB permeable drug leads, monoamine oxidase B inhibitors, neuroprotective effects, cortical neuron survival, neurite network outgrowth, MAO-B.

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