Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.


Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.


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Kitson PJ, Marie G, Francoia JP, Zalesskiy SS, Sigerson RC, Mathieson JS, Cronin L. Science. 2018 Jan 19;359(6373):314-319. doi: 10.1126/science.aao3466. PubMed PMID: 29348235.


Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals

Keywords: reactionware, 3D printing, pharmaceuticals.



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