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- Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products.Related ArticlesRecent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products. Molecules. 2019 Apr 18;24(8): Authors: Luo S, Dong SH Abstract Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of their biosynthetic pathways, and the ... read more
- Healthcare providers’ role regarding the safe and appropriate use of herbal products by breastfeeding mothers: A systematic literature review.Related ArticlesHealthcare providers' role regarding the safe and appropriate use of herbal products by breastfeeding mothers: A systematic literature review. Complement Ther Clin Pract. 2019 May;35:131-147 Authors: Zheng T, Yao D, Chen W, Hu H, Ung COL, Harnett JE Abstract BACKGROUND: Breastfeeding women often use herbal products to increase their milk supply. The aim of this study was to summarize the literature about the role of healthcare providers in advising breastfeeding women about herbal product use. METHODS: Pubmed, ScienceDirect, Web of Science, and CINAHL databases were searched for articles written in English using the Keywords: "breastfeeding" or "lactation" and "herbal ... read more
- In silico prediction and characterisation of secondary metabolite clusters in the plant pathogenic fungus Verticillium dahliae.Related ArticlesIn silico prediction and characterisation of secondary metabolite clusters in the plant pathogenic fungus Verticillium dahliae. FEMS Microbiol Lett. 2019 Apr 20;: Authors: Shi-Kunne X, Jové RP, Depotter JRL, Ebert MK, Seidl MF, Thomma BPHJ Abstract Fungi are renowned producers of natural compounds, also known as secondary metabolites (SMs) that display a wide array of biological activities. Typically, the genes that are involved in the biosynthesis of SMs are located in close proximity to each other in so-called secondary metabolite clusters (SMCs). Many plant-pathogenic fungi secrete SMs during infection in order to promote disease establishment, for instance as cytocoxic ... read more
- Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.Related ArticlesTargeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells. Life Sci. 2019 Apr 17;: Authors: Xu X, Huang L, Zhang Z, Tong J, Mi J, Wu Y, Zhang C, Yan H Abstract AIMS: Alantolactone (ALT) is active component of natural product Inula helenium with a lot of pharmacological effects, including anti-tumor effect. The present work aimed to explore the antitumor effect of ALT in B cell acute lymphoblastic leukemia (B-ALL). MAIN METHODS: B-ALL cells were treated with various concentrations of ALT, and then trypan blue assay, Annexin V/PI staining assay, PI staining assay, western blot ... read more
- There’s a Downside to Vigorous Interval TrainingSUNDAY, April 21, 2019 -- High-intensity interval training may boost your fitness at a cost -- perhaps increasing your risk for injuries. This popular type of training combines aerobics, weight lifting and calisthenics at maximum effort, followed by ... read more
- Softgel Capsules Market 2019 | Industry Share, Size, Gross Margin, Trend, Future Demand …More than 50 percent of consumers are willing to pay a premium price for a natural product, and nearly half say that they are willing to pay more for ... read more
- An improved method to produce clinical scale natural killer cells from human pluripotent stem cellsHuman natural killer (NK) cell-based adoptive anti-cancer immunotherapy has gained intense interest with many clinical trials actively recruiting patients to treat a variety of both hematological malignancies and solid tumors. Most of these trials use primary NK cells isolated either from peripheral blood (PB-NK cells) or umbilical cord blood (UCB-NK cells), though these sources require NK cell collection for each patient leading to donor variability and heterogeneity in the NK cell populations. In contrast, NK cells derived human embryonic stem cells (hESC-NK cells) or induced pluripotent stem cells (hiPSC-NK cells) provide more homogeneous cell populations that can be grown at ... read more
- Machine learning predicts rapid relapse of triple negative breast cancerPurpose: Metastatic relapse of triple-negative breast cancer (TNBC) within 2 years of diagnosis is associated with particularly aggressive disease and a distinct clinical course relative to TNBCs that relapse beyond 2 years. We hypothesized that rapid relapse TNBCs (rrTNBC; metastatic relapse or death <2 years) reflect unique genomic features relative to late relapse (lrTNBC; >2 years). Patients and Methods: We identified 453 primary TNBCs from three publicly-available datasets and characterized each as rrTNBc, lrTNBC, or 'no relapse' (nrTNBC: no relapse/death with at least 5 years follow-up). We compiled primary tumor clinical and multi-omic data, including transcriptome (n=453), copy number alterations ... read more
- UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTsUNC-45A is a ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system. However, emerging studies from both our and other laboratories support a role of UNC-45A outside of actomyosin regulation. This includes studies showing that UNC-45A: regulates gene transcription, co-localizes and biochemically co-fractionates with gamma tubulin and regulates centrosomal positioning, is found in the same subcellular fractions where MTassociated proteins are, and is a mitotic spindle-associated protein with MT destabilizing activity in absence of the actomyosin system. Here, we extended our previous findings ... read more
- Fusarium verticillioides SNARE protein FvSyn1 harbors two key functional motifs that play selective roles in fungal development and virulenceFusarium verticillioides is one of the key fungal pathogens responsible for maize stalk rots. While stalk rot pathogens are prevalent worldwide, our understanding of stalk rot virulence mechanism in pathogenic fungi is still very limited. We previously identified F. verticillioides FvSYN1 gene, which was demonstrated to plays an important role in maize stalk rot virulence. FvSyn1 belongs to a family of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that play critical roles in a variety of developmental processes. In this study, we further characterized the cellular features of FvSyn1 protein motifs in F. verticillioides development and virulence. We generated ... read more
- 3,3′-Diindolylmethane Dose-Dependently Prevents Advanced Prostate Cancer3,3'-Diindolylmethane (DIM) is an acid-derived dimer of indole-3-carbinol, found in many cruciferous vegetables, such as broccoli, and has been shown to inhibit prostate cancer (PCa) in several in vitro and in vivo models. We demonstrated that DIM stimulated both estrogen receptor alpha (ER) and estrogen receptor beta (ER{beta}) transcriptional activities and propose that ER{beta} plays a role in mediating DIM's inhibition on cancer cell growth. To further study the effects of DIM on inhibiting advanced PCa development, we tested DIM in TRAMP (TRansgenic Adenocarcinoma of the Mouse Prostate) mice. The control group of mice were fed a high fat diet. ... read more
- PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 and CTLA4 PathwaysCombined immunotherapy with anti-PD-1/PD-L1 and anti-CTLA4 has resulted in superior clinical responses compared to single agent therapy. The underlying mechanisms for this synergy have yet to be elucidated and investigations have largely focused on cellular interactions. Herein, we report a molecular crosstalk in which the PD-1 ligand PD-L1 and the CTLA4 ligand CD80 heterodimerize in cis. This heterodimerization blocks both PD-L1:PD-1 and CD80:CTLA4 interactions, but preserves the ability of CD80 to activate the T cell costimulatory receptor CD28. Remarkably, PD-L1 expression on antigen presenting cells (APCs) protects CD80 from CTLA4 mediated trans-endocytosis, and the therapeutic PD-L1 blockade antibody atezolizumab paradoxically ... read more
- A Genetically Encoded Fluorescent Sensor Enables Real-time Detection of the Intracellular GTP:GDP RatioThe interconversion of guanosine triphosphate (GTP) and guanosine diphosphate (GDP) is integral to a wide variety of biological cellular activities. However, analytical methods which directly detect the ratio of intracellular GTP and GDP concentrations have not been available. Herein, we report GNEPS, a genetically encoded fluorescent sensor that enables real-time monitoring of the GTP:GDP ratio, which is a fusion protein comprising a eukaryotic G-protein and a circularly permuted yellow fluorescent protein. GNEPS has distinct fluorescence spectra between its GTP-bound and GDP-bound states. Its apparent fluorescence signal therefore depends upon the competitive binding of GTP and GDP. Live cell imaging experiments ... read more
- Solution of the FISH-Hi-C paradox for Human Interphase ChromosomesHi-C experiments are used to infer the contact probabilities between loci separated by varying genome lengths. Contact probability should decrease as the spatial distance between two loci increases. However, studies comparing Hi-C and FISH data show that in some cases the distance between one pair of loci, with larger Hi-C readout, is paradoxically larger compared to another pair with a smaller value of the contact probability. We solve the FISH-Hi-C paradox using a theory based on a Generalized Rouse Model for Chromosomes (GRMC). The FISH-Hi-C paradox arises because the cell population is highly heterogeneous, which means that a given contact ... read more
- Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout miceThe fucose alpha(1,2) galactose structure (H antigen) is synthesized by alpha 1,2 fucosyltransferases Fut1, Fut2 and Sec1. H antigen has been reported to be involved in cancer progression, neurite migration, synaptic plasticity, host-microbe interaction, blastocyst implantation, and the maintenance of gut microbiome. Genetic depletion of Fut1 or Fut2 only cause defects of alpha1,2 fucosylation in limited tissues because of enzyme redundancy. In this study, we generated mice with deficiencies in Fut1, Fut2, and Sec1 genes to deplete H antigen through BAC Engineering for the generation of ES Cell-Targeting construct. The homogenous triple knockout mice showed no significant decrease of viability ... read more
- Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence timeRho-kinase (Rok) is a major myosin II activator during morphogenesis. In the Drosophila embryonic salivary gland placode Rok is planar polarised at the tissue boundary, through a negative regulation by the apical polarity protein Crumbs that is anisotropically localised at the boundary. However, in inner cells of the placode both Crumbs and Rok are isotropically enriched at junctions. We propose a model that reconciles both behaviours through modulation of Rok membrane residence time by Crumbs and downstream effectors. Using FRAP in embryos expressing endogenously-tagged Rok combined with in silico simulations, we find that the lower membrane dissociation rate (koff) of ... read more
- Internal friction can be measured with the Jarzynski equalityA simple protocol for the extraction of the internal friction coefficient of polymers is presented. The proposed scheme necessitates repeatedly stretching the polymer molecule, and measuring the average work dissipated in the process by applying the Jarzynski equality. The internal friction coefficient is then estimated from the average dissipated work in the hypothetical limit of zero solvent viscosity. The validity of the protocol is established through Brownian dynamics simulations of a single-mode spring-dashpot model for a polymer. Well-established single-molecule manipulation techniques, such as optical tweezer-based pulling, can be used to implement the suggested protocol experimentally. ... read more
- Organising the cell cycle in the absence of transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionallyThe cell division cycle of the unicellular eukaryote Trypanosome brucei is tightly regulated despite the paucity of transcriptional control that results from the arrangement of genes in polycistronic units and lack of dynamically regulated transcription factors. To identify the contribution of dynamic phosphorylation to T. brucei cell cycle control we have combined cell cycle synchronisation by centrifugal elutriation with quantitative phosphoproteomic analysis. Cell cycle regulated changes in phosphorylation site abundance (917 sites, average 5-fold change) were more widespread and of a larger magnitude than changes in protein abundance (443 proteins, average 2-fold change) and were mostly independent of each other. ... read more
- Coordinator, Clinical Research Program (Regulatory)- Thoracic/Head & Neck Med OncologyCoordinator, Clinical Research Program - Thoracic/Head & Neck Med Oncology Mission While encompassing the overall mission of MD Anderson Cancer Center, the particular goals of the Department of Thoracic/Head and Neck Medical Oncology are to provide the highest quality of care to our patients and to advance the treatment and prevention of aerodigestive cancers through innovative clinical and laboratory research. Our investigations involve many of the most promising molecularly-targeted agent ... read more
- Research Interviewer – Palliative Care & Rehab Med ResearchResearch Interviewer - Palliative Care & Rehab Med Research The Department of Palliative, Rehabilitation & Integrative Medicine focuses on the delivery of supportive care, palliative care, physical medicine, rehabilitation and integrative medicine to MD Anderson patients and support to their family members. Our department is organized into three sections. Our Symptom Control and Palliative Care Section delivers clinical care upon referral from MD Anderson faculty to any area of the hospital, ... read more
- Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo.Related ArticlesOrientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo. Antimicrob Agents Chemother. 2018 04;62(4): Authors: Kock F, Hauptmann M, Osterloh A, Schäberle TF, Poppert S, Frickmann H, Menzel KD, Peschel G, Pfarr K, Schiefer A, König GM, Hoerauf A, Fleischer B, Keller C Abstract Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel antiinfectives against scrub typhus. Corallopyronin A (CorA) is a novel α-pyrone compound synthesized by ... read more
- Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation.Related ArticlesAntiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation. Front Oncol. 2019;9:224 Authors: Sousa ML, Preto M, Vasconcelos V, Linder S, Urbatzka R Abstract Natural products are interesting sources for drug discovery. The natural product oxadiazine Nocuolin A (NocA) was previously isolated from the cyanobacterial strain Nodularia sp. LEGE 06071 and here we examined its cytotoxic effects against different strains of the colon cancer cell line HCT116 and the immortalized epithelial cell line hTERT RPE-1. NocA was cytotoxic against colon cancer cells and immortalized cells under conditions of exponential growth but was ... read more
- Synthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2-Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids.Related ArticlesSynthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2-Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids. Org Lett. 2019 Apr 19;: Authors: Hussain N, Bhardwaj M, Ahmed A, Mukherjee D Abstract Pd-catalyzed carbonylative cross-coupling reactions of 2-iodoglycals have been developed for the synthesis of sugar-based arylones and ynones using formic acid as the carbonyl source. Whereas acetyl-protected arylones lead to the formation of highly substituted furan derivatives in the presence of Lewis acid, benzyl-protected arylones furnished the 3-deoxy sugar derivative. In the presence of nucleophiles, an attack took place on the C-1 or C-3 carbon ... read more
- Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways.Related ArticlesAntifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways. Pharmacol Rep. 2019 Jan 15;71(3):409-416 Authors: Wu B, Wang R, Li S, Wang Y, Song F, Gu Y, Yuan Y Abstract BACKGROUND: Liver fibrosis is a chronic lesion which ultimately results in cirrhosis and possible death. Although the high incidence and lethality, few therapies are effective for liver fibrosis. Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a natural product extracted from cortex fraxini, has exhibited a significant hepatoprotective and anti-fibrotic properties. However, the underlying mechanism of the anti-hepatic fibrotic property remains unknown. METHODS: 48 Male Sprague Dawley ... read more
- Sodium Sulfate Market Investigation by Application, Technology and Product TypeSodium Sulfate Global Market 2019-2024 covers market characteristics, size and growth, segmentation, regional breakdowns, competitive landscape, ... read more
- Finite element simulation and efficient algorithm for fractional Cahn-Hilliard equationTitle: Finite element simulation and efficient algorithm for fractional Cahn-Hilliard equation Author(s): Wang, Feng; Chen, Huanzhen; Wang, Hong Source: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, 356: 248-266 AUG 15 2019 Document Type: Article ... read more
- Development of t-z curve for piles in sands under uplift forceTitle: Development of t-z curve for piles in sands under uplift force Author(s): Ashour, Mohamed; Altahrany, Ayman; Abbas, Aser Source: INNOVATIVE INFRASTRUCTURE SOLUTIONS, 4 (1): DEC 2019 Document Type: Article ... read more
- WHAT IS PUERTO RICO?Title: WHAT IS PUERTO RICO? Author(s): Issacharoff, Samuel; Bursak, Alexandra; Rennie, Russell; et al. Source: INDIANA LAW JOURNAL, 94 (1): WIN 2019 Document Type: Article ... read more
- BC RANCH II V. COMMISSIONER: A FLEXIBLE APPROACH TO PERPETUAL CONSERVATION EASEMENTSTitle: BC RANCH II V. COMMISSIONER: A FLEXIBLE APPROACH TO PERPETUAL CONSERVATION EASEMENTS Author(s): Wolfe, Victoria Source: INDIANA LAW JOURNAL, 94 (1): 331-354 WIN 2019 Document Type: Article ... read more
- THE COMPLIANCE PROCESSTitle: THE COMPLIANCE PROCESS Author(s): Root, Veronica Source: INDIANA LAW JOURNAL, 94 (1): 203-251 WIN 2019 Document Type: Article ... read more
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