Aggregation of relevant feeds from the web.
- A selective electrochemical sensor for caffeic acid and photocatalyst for metronidazole drug pollutant – A dual role by rod-like SrV2O6.Related ArticlesA selective electrochemical sensor for caffeic acid and photocatalyst for metronidazole drug pollutant - A dual role by rod-like SrV2O6. Sci Rep. 2017 08 03;7(1):7254 Authors: Karthik R, Kumar JV, Chen SM, Kumar PS, Selvam V, Muthuraj V Abstract In the present study, well-defined one-dimensional (1D) rod-like strontium vanadate (SrV2O6) was prepared by simple hydrothermal method without using any other surfactants/templates. The successful formation of rod-like SrV2O6 was confirmed by various analytical and spectroscopic techniques. Interestingly, for the first time the dual role of as-prepared rod-like SrV2O6 were employed as an electrochemical sensor for the detection of ... read more
- Pharmacokinetic evaluation of medicinally important synthetic N,N’ diindolylmethane glucoside: Improved synthesis and metabolic stability.Related ArticlesPharmacokinetic evaluation of medicinally important synthetic N,N' diindolylmethane glucoside: Improved synthesis and metabolic stability. Bioorg Med Chem Lett. 2019 Feb 11;: Authors: Magotra A, Gour A, Sharma DK, Dash AK, Singh G, Mukherjee D, Nandi U Abstract An improved route for the synthesis of N,N'-diindolyl methane (DIM) glycosides has been developed by using Fe/Al pillared clay catalyst. In-silico pharmacokinetics followed by in-vitro studies like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, RBC partitioning, metabolic stability in different liver microsomes and its in-vitro-in-vivo extrapolation were conducted for the most potent derivative namely NGD16. The compound ... read more
- Synthesis of Cytospolide Analogues and Late-State Diversification Thereof.Related ArticlesSynthesis of Cytospolide Analogues and Late-State Diversification Thereof. J Org Chem. 2019 Feb 19;: Authors: Ehrlich G, Stark CBW Abstract The cytospolides are a novel group of fungal secondary metabolites first described in 2011. Although all 17 natural derivatives share the same C-14 polyketide backbone, they exhibit a fairly broad structural diversity regarding their oxygenation and acetylation pattern as well as macrolide structure, e.g. monocyclic nonanolide core or bicyclic ring systems with a bridging THF ring. In the present work, the prospects for an extension of the structural diversity of cytospolides have been investigated. Based on a previously established ... read more
- Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A.Related ArticlesGrob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A. Org Lett. 2019 Feb 19;: Authors: Cao L, Wang C, Wipf P Abstract A ketene [2 + 2]-addition, an intramolecular aldol reaction, a Suzuki-Miyaura coupling, and a chemoselective lactam reduction were used to prepare a late-stage precursor of haouamine A. Exposure to acid led to a Grob-type fragmentation of the strained 3-aza[7]paracyclophane ring, followed by a tandem Pictet-Spengler reaction of the intermediate iminium ion and conversion to a novel 1,4a-propanocyclopenta[ b]pyridine. This cascade reaction might also be relevant for the mechanism of action of the natural ... read more
- Molecular crypsis by pathogenic fungi using human factor H. A numerical model.Related ArticlesMolecular crypsis by pathogenic fungi using human factor H. A numerical model. PLoS One. 2019;14(2):e0212187 Authors: Lang SN, Germerodt S, Glock C, Skerka C, Zipfel PF, Schuster S Abstract Molecular mimicry is the formation of specific molecules by microbial pathogens to avoid recognition and attack by the immune system of the host. Several pathogenic Ascomycota and Zygomycota show such a behaviour by utilizing human complement factor H to hide in the blood stream. We call this type of mimicry molecular crypsis. Such a crypsis can reach a point where the immune system can no longer clearly distinguish between self ... read more
- Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A. Molecules. 2019 Feb 16;24(4): Authors: Ibric A, Eckerstorfer S, Eder M, Louko I, Tunjic L, Heffeter P, Schueffl HH, Marian B, Haider N Abstract Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of the natural product Luotonin A (a known Topoisomerase I inhibitor) was synthesized. In both strategies, intramolecular cycloaddition reactions are the key step. The target compounds were obtained in good yields by mild catalytic transfer hydrogenation of the corresponding nitro precursors. In-vitro evaluation of the antiproliferative ... read more
- Research and analysis: Enterovirus: strain characterisationGraphs showing cumulative strain characterisation data for enterovirus. ... read more
- Doctoral Position in the area of charge transfer at interfacesThe Cluster of Excellence Living, Adaptive and Energy-autonomous Materials Systems (liv MatS) is offering a Doctoral Position in the area of charge transfer at interfaces Part-time position (65 %), Start-date: At the earliest possible date. The Cluster of Excellence liv MatS develops completely novel, bioinspired materials systems that adapt autonomously to various environments and harvest clean energy from their surroundings. The intention of these purely technical – yet in a behav… ... read more
- Herb of the Month: Cardamom, the Queen of SpicesBy Maryann Readal, Secretary, The Herb Society of America
Cardamom, Elettaria cardamomum, is called the Queen of Spices because of its many uses as a medicine and as a flavoring in food and drink. It is an important ingredient in Indian cooking and in Scandinavian baking. And– it is the third most expensive spice in the world. In the ginger family, cardamom is native to India. It grows in my Zone 8b garden but will not flower and produce seeds since it does not have the ... read more - How To Cope with Cabin Fever At Winter’s EndThe last weeks of winter can oftentimes feel the most challenging. The initial brisk excitement of winter is behind us and the frigid days seem longer and more bone-chilling than ever. At this point of the season, we can start to feel a little “stir crazy” in anticipation of the warmer spring days ahead when... Read More The post How To Cope with Cabin Fever At Winter’s End appeared first on Herbal Academy. ... read more
- Tilray® to Acquire Manitoba Harvest, the World’s Largest Hemp Food CompanyManitoba Harvest's 100% all-natural product lineup includes hemp hearts, hemp protein powder and hemp snacks and are currently carried in about ... read more
- PhD Candidate (m/w/d) in Immune-Lipid crosstalkThe Institute for Molecular Cardiovascular Research (IMCAR), Medical Faculty of RWTH Aachen University is seeking a PhD Candidate (m/w/d) in Immune-Lipid crosstalk The position is a part-time position (25,03 h/w) and is initially funded until 31st December 2021 with the option of extension. The salary corresponds to level 65% of 13 TV-L. The successful candidate has the opportunity to pursue a doctoral degree. It has been recently shown that chronic kidney disease (CKD) patients hav… ... read more
- Flame Retardant Chemicals Market Research Report: CAGR (%) Comparison by Type, Capacity …Flame Retardant Chemicals market report provides detail analysis on current competitive situation of Flame Retardant Chemicals market dominated ... read more
- The pro-choice license to killHow is it possible that the natural product of sexual intercourse – which includes you, me and everybody else – may be disposed of at will, like trash? ... read more
- Legislative breakthrough: SPC manufacturing waiver to be introduced for export and stockpilingOswin Ridderbusch and Alexa von UexküllThe introduction of an SPC manufacturing waiver in the European Union is now all but a done deal. Following the European Commission’s initial proposal for a regulation amending Regulation (EC) 469/2009 on SPCs for medicinal products (COM(2018) 317 final) issued on 28 May 2018, the European Parliament’s Committee on Legal Affairs (JURI) adopted its final report and decided to open the inter-institutional “trilogue” negotiations between Parliament, Council and Commission at the end of January 2019, while the Council in parallel agreed its own negotiating mandate on 16 January 2019, as previously reported on this blog. ... read more
- Free Ship From Panda BalmIt is a reflection of what is going on inside your body. It is, therefore, paramount to take great care of the skin. Currently, there are numerous skin care ... read more
- Keen stargazers enthralled with super moonAccording to NASA, a super moon occurs when the moon's orbit is closest to the earth and also coincides with a full moon. Tuesday's night supermoon is the closest it will get to the Earth's orbit this year - approximately 360,000km. ... read more
- Public Health monitoring measles outbreaks in US, PhilippinesHow vaccines can protect communities. Dr. Jennifer Mullendore dicusses how vaccinations can protect communities against highly contagious infectious diseases like measles. ... read more
- China space ambitions move into higher orbit with solar-powered space stationFollowing its successful venture to the far side of the Moon, China's space ambitions are moving into a higher orbit. The Chinese space agency will now be focusing to build a solar-powered space station. ... read more
- Positon openings — Shanghai Research Center for Brain Science and Brain-Inspired IntelligenceAs part of a major Chinese brain initiative, Shanghai city and the Chinese Academy of Sciences recently inaugurated Shanghai Research Center for Brain Science and Brain-Inspired Intelligence (henceforth abbreviated as Shanghai Brain/AI Center). The Shanghai Brain/AI Center is structurally designed to foster cross-disciplinary and collaborative research to tackle major challenges in neuroscience, studies of brain diseases, artificial intelligence. The Center aims at recruiting top-quality scienti… ... read more
- NASA developing models to predict conflicts among crew members for manned Mars missionsScientists are studying the behaviour of analogue astronaut crews on mock missions, complete with isolation, sleep deprivation, specially designed tasks and mission control. ... read more
- State & Union: This month’s supermoon biggest of the yearThis month's full supermoon, which peaked earlier Tuesday, resulted from this month's full moon coincides with the point in orbit in which the moon is closest to Earth, according to the Old Farmer's Almanac. ... read more
- How Can Dermatitis Herpetiformis Be Treated?Dermatitis herpetiformis, also known as Duhring's disease or gluten rash is a difficult condition to live with. It's an autoimmune blistering disorder which is characterized by itchy, burning and blistering skin rash, mostly affecting knees, scalp, elbows, back and buttocks. Dermatitis herpetiformis considered to be caused by allergic reaction to ingestion of gluten. Usually patients of dermatitis herpetiformis have celiac disease (Gluten sensitive enteropathy). Celiac disease is an autoimmune disease in which patient cannot digest gluten, a protein found in wheat, rye and barley. Some people may confuse it with herpes virus infection due to the name given to it ... read more
- Beta-Carotene Market Breakdown, Development and New Market opportunities & ForecastsThe Beta-Carotene Market report recently incorporated in the massive research report database of Pioneer Reports which provides detailed analytical ... read more
- Global Organic Spices Market 2019 – Rapid Organic, Sapthsathi Organic Agriculture Project …The key companies are Rapid Organic, Sapthsathi Organic Agriculture Project (S.O.A.P), ORGANIC SPICES, Live Organics, Frontier Natural Product ... read more
- More social interaction keeps older adults more activeSocial isolation and loneliness pose major health risks to older adults, and research has shown that social isolation is as bad for your health as smoking 15 cigarettes a day. ... read more
- Zombie Deer Disease? (No, it’s just CWD)SPRINGFIELD -- A new report from the Centers for Disease Control and Prevention the brain-wasting disease that infects deer could possibly be contagious to humans. ... read more
- Boulder Flu Risk Still High; Two Colorado Deaths This SeasonThe flu is now widespread in nearly the entire country, according to the latest figures from the CDC. By Mara Abbott, Patch Staff | Feb 19, 2019 11:20 pm ET | Updated Feb 19, 2019 11:20 pm ET. ... read more
- Avera Medical Minute: What are the dangers of vaping?SIOUX FALLS, S.D. - The Food and Drug Administration is calling it an epidemic. The commissioner of the FDA, Dr. Scott Gottlieb, said the number of teenagers using electronic cigarettes is concerning. ... read more
- Exciting PhD positions at the European Molecular Biology Laboratory (EMBL)About the team/job The European Molecular Biology Laboratory (EMBL) invites you to apply for PhD positions in Heidelberg, Barcelona, Grenoble, Hamburg, Hinxton (near Cambridge) and Rome. Would you like to contribute your creativity to an international team of scientists from all disciplines focusing on basic research in the area of molecular life sciences? We invite candidates with background in Biology, Chemistry, Physics, Mathematics, Computer Science, Engineering and Molecular Medicine to … ... read more
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The International Natural Product Sciences Taskforce (INPST) maintains up-to-date lists with conferences, grants and funding opportunities, jobs and open positions, and journal special issues with relevance for the area of phytochemistry and food chemistry, pharmacology, pharmacognosy research, and natural product science.