Repurposing Anticancer Drugs for the Management of COVID-19

Abstract

Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion, thus regarded as a global public health emergency. The existing therapeutic options for COVID-19 beyond the intensive supportive care are limited, with an undefined or modest efficacy reported so far. Drug repurposing represents an enthusiastic mechanism to use approved drugs outside the scope of their original indication and accelerate the discovery of new therapeutic options. With the emergence of COVID-19, drug repurposing has been largely applied for early clinical testing. In this Review, we discuss some repurposed anticancer drugs for the treatment of COVID-19 and under investigation in clinical trials or proposed for the clinical testing.

Read full text: El Bairi K, Trapani D, Petrillo A, Le Page C, Zbakh H, Daniele B, Belbaraka R, Curigliano G, Afqir S. Repurposing Anticancer Drugs for the Management of COVID-19. Eur J Cancer. 2020 Sep 22. doi: 10.1016/j.ejca.2020.09.014. Epub ahead of print. PMCID: PMC7508523.

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Tropical rainforest, Queensland, Australia. Photo by Dr. Rohan Davis.
Analytical equipment. Photo by Atanas G. Atanasov.
Hep-2 signal activated cells. Image by Dr. Vassilis Doucas.
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HEK293T cells. Photo by Atanas G. Atanasov.
Tropical rainforest, Queensland, Australia. Photo by Dr. Rohan Davis.
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Laboratory equipment. Photo by Atanas G. Atanasov.
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The Valley of Flowers, Himalaya, India. Photo by Dr. Rajeshwari Singh.
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Keywords: COVID-19, SARS-CoV-2, Anticancer drugs, Drug repurposing, #Pharmaceuticals, #Pharma.

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