Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis

Abstract:

Introduction: The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).

Material and methods: Data sources: PubMed-Medline, Web of Science, Co-chrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I 2 index. Main outcome: Level of CRP after Mg supplementation.

Results: From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD)-1.33 mg/l; 95% CI:-2.63 to-0.02, het-erogeneity p < 0.123; I 2 = 29.1%). The WMD for interleukin 6 was-0.16 pg/dl (95% CI:-3.52 to 3.26, heterogeneity p = 0.802; I 2 = 2.3%), and 0.61 mg/dl (95% CI:-2.72 to 1.48, p = 0.182, heterogeneity p = 0.742; I 2 = 6.1%) for fasting blood glucose. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of Mg supplementation (slope:-0.004; 95% CI:-0.03, 0.02; p = 0.720) or duration of follow-up (slope:-0.06; 95% CI:-0.37, 0.24; p = 0.681).

Conclusions: This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level. RCTs with a larger sample size and a longer follow-up period should be considered for future investigations to give an unequivocal answer.

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Reference:

Mazidi M, Rezaie P, Banach M. Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis. Arch Med Sci. 2018 Jun;14(4):707-716. doi: 10.5114/aoms.2018.75719. Epub 2018 May 11. Review. PubMed PMID: 30002686; PubMed Central PMCID: PMC6040119.

Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis
Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis

Keywords: magnesium supplements, serum C-reactive protein, systematic review and meta-analysis, randomised controlled trials (RCTs).

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